|
KMID : 1161420210240060645
|
|
Journal of Medicinal Food
2021 Volume.24 No. 6 p.645 ~ p.652
|
|
|
Maillard Reaction Products and Phenolic Compounds from Roasted Peanut Flour Extracts Prevent Scopolamine-Induced Amnesia Via Cholinergic Modulation and Antioxidative Effects in Mice
|
|
Smach Mohamed Ali
Zarrouk Amira
Hafsa Jawhar
Gaffrej Henda
Abdallah Jihen Ben
Charfeddine Bassem
Limem Khalifa
|
|
|
Abstract
|
|
|
|
Research on the beneficial effects of Maillard reaction products (MRPs) and phenolic compounds derived from roasted peanut flour on the nervous system remains insufficient. This study aimed to evaluate the effect of a 28-day oral administration of defatted peanut extract rich in MPRs and polyphenolic compounds on the cognitive impairments and oxidative injury induced by scopolamine in a mouse model. Light and dark extracts from peanut flour were prepared by heating peanuts at 187°C for two different times (8.6 and 12.7?min) and defatted using soxhlet apparatus. The mice were orally pretreated with either roasted defatted peanuts extracts (100?mg/kg) or donepezil (3?mg/kg) for 21 days. On day 19 and until day 28, mice were injected subcutaneously with water or scopolamine (1?mg/kg body weight) 15?min after roasted defatted peanuts extracts/water feeding. Mice were subsequently subjected to a battery of behavioral tests including open field locomotor activity assay, and Morris water maze test. Brain tissues were collected to measure acetylcholine, acetylcholinesterase, and oxidative parameters (glutathione and malondialdehyde). Roasted defatted peanuts (light and dark) (100?mg/kg) treatment significantly ameliorated cognitive performance and reversed the oxidative damage when compared with the scopolamine group. These data demonstrate the defatted peanuts extracts exert potent anti-amnesic effects via the modulation of cholinergic and antioxidant activities.
|
|
|
KEYWORD
|
|
|
acetylcholinesterase, cognitive impairments, Maillard reaction products, oxidative injury, phenolic compounds, scopolamine
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|